Mayo Clinic Awarded $2.5 Million Grant To Study Use Of Snake Venom As Heart Treatment

The Mayo Clinic announced it was awarded a $2.5 million grant from the National Heart, Lung and Blood Institute, a division of the National Institutes of Health, to conduct research on the potential effects of an engineered guanylyl cyclase (GC) activator called cenderitide on cardiac or renal injuries following a heart attack. The cenderitide, invented by Mayo Clinic researchers was developed from the venom of the green mamba (Dendroaspis angusticeps) a venomous snake native to Africa.

green mamba


Mayo Clinic researchers invented a cenderitide using venom from the green mamba.

The grant will enable researchers to determine if cenderitide therapy could help to prevent the breakdown of cardiac and renal function after a heart attack and if it could help to reduce further heart failure in patients treated with the experimental medicine. The researchers believe that cenderitide, which activates two subtypes of GC receptors, can aid cardiac and renal function following a heart attack or heart failure. Mayo Clinic research fellow Fernando Martin, M.D. presented research data in November 2011 that showed cenderitide could stop the death of heart cells. The $2.5 million grant will support laboratory research as well as a proof-of-concept clinical study. The clinic will enroll 60 patients in the study in Minnesota and Florida. 

Related Articles

Passengers on Qantas Air Flight Screen Own Version of Snakes on a Plane

Scrub python spotted trying to survive on wing of plane bound for Papua New Guinea.

Motorist Runs Over 5ft. Boa Constrictor On Oahu's Pali Highway In Hawaii

There are no native land snakes in Hawaii and keeping them is illegal.

New York Animal Control Officer Charged With Running Snake Breeding Business Out Of His Home

Man also cited for keeping two Burmese pythons, which are illegal to keep in Shirley, NY.
Edit Module
Edit ModuleShow Tags Edit Module
Edit Module

Cast Your Vote

What is Your Favorite Reptile?


Edit ModuleEdit ModuleShow Tags Edit ModuleEdit Module

Find Us On facebook

Edit Module